The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Ashley A. Basiorka, Kathy L. McGraw, Erika A. Eksioglu, +17

Blood

Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

Yang Mei, Baobing Zhao, Ashley A. Basiorka, +5

Leukemia

InflammationHuman MdsBone Marrow FailureAutoimmune DiseaseImmunology +12

Novel therapeutic approach to improve hematopoiesis in low risk MDS by targeting MDSCs with the Fc-engineered CD33 antibody BI 836858

Erika A. Eksioglu, X Chen, K-H Heider, +11

Leukemia

Health SciencesHematologyImmunologyLow Risk MdsBiological Therapy +5

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

Ganesan Keerthivasan, Yang Mei, Baobing Zhao, +13

Blood

Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study

Ashley A. Basiorka, Kathy L. McGraw, Farnoosh Abbas‐Aghababazadeh, +18

The Lancet Haematology

Hematological MalignancyHealth SciencesMedicineAplastic AnemiaMixed-phenotype Acute Leukemia +10

<i>TP53</i> suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients

Gisela Cáceres, Kathy L. McGraw, Bon Ham Yip, +18

Proceedings of the National Academy of Sciences

Pro-inflammatory proteins S100A9 and tumor necrosis factor-α suppress erythropoietin elaboration in myelodysplastic syndromes

Thomas Cluzeau, Kathy L. McGraw, Brittany Irvine, +9

Haematologica

Lenalidomide Induces Lipid Raft Assembly to Enhance Erythropoietin Receptor Signaling in Myelodysplastic Syndrome Progenitors

Kathy L. McGraw, Ashley A. Basiorka, Joseph Johnson, +8

PLoS ONE

ImmunologyCell DeathImmunologic MechanismImmune DysregulationMyeloid Neoplasia +14

Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41

Ashley A. Basiorka, Kathy L. McGraw, Leentje De Ceuninck, +10

Cancer Research

ImmunologyImmune RegulationCell DeathBlood CellReceptor Turnover +19

The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes

Kathy L. McGraw, L M Zhang, Dana E. Rollison, +27

Blood Cancer Journal

Hematological MalignancyTp53 MutationMyelodysplastic SyndromesGeneticsMixed-phenotype Acute Leukemia +13