Zhenke Wen

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

Yinyin Li, Yi Shen, Ke Jin et al. · Cell Metabolism · 2019 · 174 citations · Full text

Genome Instability, Tissue Inflammation, Mitochondrial Function +7

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

Zhenke Wen, Ke Jin, Yi Shen et al. · Nature Immunology · 2019 · 148 citations

Inflammation, Synovial Tissue Inflammation, Kinase Ampk +10

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs

Zhenke Wen, Yasuhiro Shimojima, Tsuyoshi Shirai et al. · Journal of Clinical Investigation · 2016 · 134 citations · Full text

Aging, Vasculitis, T-regulatory Cell +19

Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells

Yi Shen, Zhenke Wen, Yinyin Li et al. · Nature Immunology · 2017 · 127 citations · Full text

T-regulatory Cell, Immunology, Cell Death +16

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

Yinyin Li, Yi Shen, Philipp J. Hohensinner et al. · Immunity · 2016 · 126 citations · Full text

Inflammation, Rheumatology, Rheumatoid Disorder +9