Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling

Tingting Yan, Chaoqin Shen, Penglei Jiang, +14

Signal Transduction and Targeted Therapy

Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site

Xi Jin, Penglei Jiang, Jiangshan Lian, +32

Emerging Microbes & Infections

PathologyMild Covid-19 PatientCovid-19 EpidemiologyViral Structural ProteinVirus Transmission +15

Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism

Yue Huang, Mi Shao, Xinyi Teng, +15

Cell Reports Medicine

Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction

Penglei Jiang, Zhaoru Zhang, Yongxian Hu, +9

Leukemia

ChromatinChromatin RemodelingSingle-cell Atac-seqGeneticsMedicine +11

Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells

Qiwei Wang, Ying Liu, Hui Wang, +22

Nature Communications

Single-cell RNA sequencing reveals the immunoregulatory roles of PegIFN-α in patients with chronic hepatitis B

Penglei Jiang, Hongyu Jia, Xinyue Qian, +24

Hepatology

PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus

Li Chen, Qiaoqiao Tong, Xiaowen Chen, +21

Nature Communications

Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis

Ciliang Jin, Penglei Jiang, Zhaoru Zhang, +18

Nature Communications

ImmunologyPathologyImmunologic MechanismPrimary Biliary CirrhosisCholangiopathies +24

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

Xiu‐Jian Wang, Tao Xiao, Pengjie Chen, +25

Signal Transduction and Targeted Therapy

Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism

Deyu Huang, Yingli Han, Tian Tang, +7

Experimental Hematology and Oncology