Maria Scuotto

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

Maria Scuotto, Elisa Rivieccio, Alessia Varone et al. · Nucleic Acids Research · 2015 · 46 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

Investigating the Role of T₇ and T₁₂ Residues on the Biological Properties of Thrombin-Binding Aptamer: Enhancement of Anticoagulant Activity by a Single Nucleobase Modification

Nicola Borbone, Mariarosaria Bucci, Giorgia Oliviero et al. · Journal of Medicinal Chemistry · 2012 · 46 citations

Life Sciences, Biochemistry, Molecular Biology +17

A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance

Veronica Esposito, Maria Scuotto, Antonella Capuozzo et al. · Organic & Biomolecular Chemistry · 2014 · 41 citations

Life Sciences, Biochemistry, Molecular Biology +13

Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication

Maria Scuotto, Rana Abdelnabi, Selene Collarile et al. · Bioorganic & Medicinal Chemistry · 2016 · 41 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +13

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

Anja Schaible, Rosanna Filosa, Verena Krauth et al. · Biochemical Pharmacology · 2016 · 35 citations

Medicine, Medicinal Chemistry, Pharmacology +14