NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells

Guikai Wu, Wen‐Hwa Lee, Phang‐Lang Chen

Journal of Biological Chemistry

Functional TCR T cell screening using single-cell droplet microfluidics

Aude I. Ségaliny, Guideng Li, Lingshun Kong, +5

Lab on a Chip

Tcr ChainsT-regulatory CellImmunologyDroplet MicrofluidicsImmunoediting +16

14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination

Zhenming Xu, Zsolt Zoltán Fülöp, Guikai Wu, +15

Nature Structural & Molecular Biology

Protein ExpressionGenetics14-3-3 AdaptorMolecular BiologyMolecular Genetics +5

Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1.

Guikai Wu, Xianzhi Jiang, Wen‐Hwa Lee, +1

PubMed

Hematological MalignancyGenome InstabilityTelomere Length MaintenanceNatural SciencesMixed-phenotype Acute Leukemia +9

Small Molecule Targeting the Hec1/Nek2 Mitotic Pathway Suppresses Tumor Cell Growth in Culture and in Animal

Guikai Wu, Xiaolong Qiu, Longen Zhou, +5

Cancer Research

A novel small molecule RAD51 inactivator overcomes imatinib‐resistance in chronic myeloid leukaemia

Jiewen Zhu, Longen Zhou, Guikai Wu, +10

EMBO Molecular Medicine

Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint

Randy Wei, Bryan Ngo, Guikai Wu, +1

Molecular Biology of the Cell

Nek2 KinaseSpindle Assemble CheckpointMolecular BiologyMolecular GeneticsCell Cycle +14

A novel role of the chromokinesin Kif4A in DNA damage response

Guikai Wu, Longen Zhou, Lily Khidr, +5

Cell Cycle

Dna DamageMolecular BiologyCell CycleChromokinesin Family MemberEpigenetics +17

Hice1, a Novel Microtubule-Associated Protein Required for Maintenance of Spindle Integrity and Chromosomal Stability in Human Cells

Guikai Wu, Yi-Tzu Lin, Randy Wei, +3

Molecular and Cellular Biology

Spindle IntegrityMolecular BiologyCytoskeletonCell CycleCancer Biology +20

Synthesis and Biological Evaluation of a Series of Novel Inhibitor of Nek2/Hec1 Analogues

Xiaolong Qiu, Guideng Li, Guikai Wu, +5

Journal of Medicinal Chemistry