HIROMU NAKASHIMIZU

Orally active cephalosporins. II. Synthesis and structure-activity relationships of new 7.BETA.-((Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-cephalosporins with 1,2,3-triazole in C-3 side chain.

Masaharu Kume, Tadatoshi Kubota, Yasuo Kimura et al. · The Journal of Antibiotics · 1993 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Synthesis and biological properties of 7.BETA.-((Z)-2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoylamino)-3-cephem-4-carboxylic acid (7432-S), a new oral cephem antibiotic.

Yoshio Hamashima, Tadatoshi Kubota, Kyôji Minami et al. · The Journal of Antibiotics · 1987 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Orally Active Cephalosporins. IV. Synthesis, Antibacterial Activity and Oral Absorption of 3-(1H-1,2,3-Triazol-4-yl)thiomethylthio-cephalosporins.

T. Kubota, HIROMU NAKASHIMIZU, KIYOSHI MOTOKAWA · Chemical and Pharmaceutical Bulletin · 1993 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Orally active cephalosporins. III. Synthesis and structure-activity relationships of new 3-heterocyclicthiomethylthio-7.BETA.-((Z)-2(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-cephem-4-carboxylic acids.

Masaharu Kume, Tadatoshi Kubota, Yasuo Kimura et al. · The Journal of Antibiotics · 1993 · 12 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +11

Synthesis and structure-activity relationships of 7.BETA.-((Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2-propenoylamino)-3-cephems with C-3 substitutions.

Koji Ishikura, Tadashi Kubota, Kyôji Minami et al. · The Journal of Antibiotics · 1994 · 10 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13