Continuous Crystallization of Aliskiren Hemifumarate

Justin L. Quon, Haitao Zhang, A. Alvarez, +3

Crystal Growth & Design

Process DesignChemical EngineeringChemical KineticsEngineeringCrystal Structure +11

Development of Continuous Anti-Solvent/Cooling Crystallization Process using Cascaded Mixed Suspension, Mixed Product Removal Crystallizers

Haitao Zhang, Justin L. Quon, A. Alvarez, +3

Organic Process Research & Development

Solvent ExtractionProcess IntensificationChemical EngineeringEngineeringNucleation Kinetics +12

Use of Continuous MSMPR Crystallization with Integrated Nanofiltration Membrane Recycle for Enhanced Yield and Purity in API Crystallization

Steven Ferguson, Franziska Ortner, Justin L. Quon, +4

Crystal Growth & Design

Chemical EngineeringMembrane TechnologyEngineeringEnhanced YieldApi Crystallization +13

Application of Model-Free and Model-Based Quality-by-Control (QbC) for the Efficient Design of Pharmaceutical Crystallization Processes

Botond Szilágyi, Ayşe Eren, Justin L. Quon, +2

Crystal Growth & Design

Process DesignDirect Nucleation ControlAgglomeration Degree MinimizationEngineeringIndustrial Engineering +13

Application of feedback control and in situ milling to improve particle size and shape in the crystallization of a slow growing needle-like active pharmaceutical ingredient

Yang Yang, Kanjakha Pal, Andy Koswara, +6

International Journal of Pharmaceutics

Materials ScienceEngineeringMicrofabricationDrug ManufacturePharmaceutical Technology +7

Experimental Investigation of an Integrated Crystallization and Wet-Milling System with Temperature Cycling to Control the Size and Aspect Ratio of Needle-Shaped Pharmaceutical Crystals

Ayşe Eren, Botond Szilágyi, Justin L. Quon, +2

Crystal Growth & Design

EngineeringMechanical EngineeringPowder CompactionChemistrySoft Matter +15

Templated Nucleation of Acetaminophen on Spherical Excipient Agglomerates

Justin L. Quon, K. Chadwick, Geoffrey P. F. Wood, +4

Langmuir

Crystal StructureSupramolecular AssemblyEngineeringSpherical AgglomeratesSpherical Agglomeration +10

Application of Ultra-Performance Liquid Chromatography as an Online Process Analytical Technology Tool in Pharmaceutical Crystallization

Yang Yang, Chuntao Zhang, Kanjakha Pal, +5

Crystal Growth & Design

Ultra-performance Liquid ChromatographySeparation ScienceGas ChromatographyOnline Uplc-based ApplicationsMedicine +10

Monitoring and digital design of the cooling crystallization of a high-aspect ratio anticancer drug using a two-dimensional population balance model

Botond Szilágyi, Ayşe Eren, Justin L. Quon, +2

Chemical Engineering Science

EngineeringPharmaceutical TechnologyDigital DesignBiomedical EngineeringCrystallography +1

Digital Design of the Crystallization of an Active Pharmaceutical Ingredient Using a Population Balance Model with a Novel Size Dependent Growth Rate Expression. From Development of a Digital Twin to <i>In Silico</i> Optimization and Experimental Validation

Botond Szilágyi, Ayşe Eren, Justin L. Quon, +2

Crystal Growth & Design

Active Pharmaceutical IngredientEngineeringIndustrial EngineeringProcess DevelopmentCsd Dynamics +20