A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2

Victor S. Goldmacher, Laura M. Bartle, Anna Skaletskaya, +10

Proceedings of the National Academy of Sciences

Molecular VirologyMitochondrial FunctionApoptosisImmunologyViral Pathogenesis +13

A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation

Anna Skaletskaya, Laura M. Bartle, Thomas Chittenden, +3

Proceedings of the National Academy of Sciences

Mutant VicaCaspase-8 ActivationViral Ul36 GeneApoptosisImmunology +10

SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies

Jutta Deckert, Marie-Cécile Wetzel, Laura M. Bartle, +14

Clinical Cancer Research

Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria

Damien Arnoult, Laura M. Bartle, Anna Skaletskaya, +6

Proceedings of the National Academy of Sciences

Mitochondrial Membrane PermeabilizationMitophagySignal TransductionVmia MutantsMitochondrial Function +12

Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses

A. Louise McCormick, Anna Skaletskaya, Peter A. Barry, +2

Virology

Caspase 8-Induced ApoptosisMolecular VirologyApoptosisViral PathogenesisImmunology +9

An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria

Delphine Poncet, Nathanaël Larochette, Anne‐Laure Pauleau, +12

Journal of Biological Chemistry

The Sequence and Antiapoptotic Functional Domains of the Human Cytomegalovirus UL37 Exon 1 Immediate Early Protein Are Conserved in Multiple Primary Strains

Wail Hayajneh, Anamaris M. Colberg‐Poley, Anna Skaletskaya, +5

Virology

Antiapoptotic Functional DomainsMolecular VirologyMultiple Primary StrainsPathogenesisViral Pathogenesis +5

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates

Wěi Li, Karen Veale, Qifeng Qiu, +15

ACS Medicinal Chemistry Letters

Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing

Wayne C. Widdison, Jose F. Ponte, Jennifer A. Coccia, +18

Bioconjugate Chemistry

ApoptosisImmunologyCell DeathChemical BiologyImmunotherapy +20

The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization

Damien Arnoult, Anna Skaletskaya, Jérôme Estaquier, +2

APOPTOSIS

Mitochondrial FunctionApoptosisImmunologyAntiviral ResponsePathology +5