21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T553,Nanocatalytic medicine was attracting considerable attention, owing to the specific treatment by the intrinsic chemical reactions within tumors. However, the insufficient hydrogen peroxide (H2O2) and unsuitable pH value limited its application. Herein, a tumor microenvironment (TME) responsive multifunctional nanoprobe with self-accelerating cascade catalysis (MPB@CeO2-GOx) was developed for enhanced catalytic therapy, in which ultrasmall cerium oxide (CeO2) and glucose oxidase (GOx) were modified on mesoporous Prussian blue (MPB). The developed MPB@CeO2@-GOx nanoprobes exhibited the dual-nanozyme activity of catalase (CAT) and peroxidase (POD), by which the O2 and hydroxyl radical (·OH) were generated by Ce4+ and Ce3+. Moreover, the sufficient O2 promoted the glucose consumption of GOx, and the generated H2O2 and gluconic acid further enhanced the catalytic therapy by reducing pH value, by which ·OH yield increased by 26.21%. In addition, the photothermal effect of MPB also significantly improved the POD activity of CeO2. Compared with MPB@CeO2, the cell survival reduced from 20.8% to 3.8%, and the tumor growth was completely inhibited. Therefore, by self-supplying O2/H2O2 and reducing pH value, the developed MPB@CeO2-GOx nanoprobes with self-accelerating cascade reactions achieved PTT and enhanced catalytic therapy against breast cancer.23:T4da,Tumor microenvironment (TME) responsive chemodynamic therapy (CDT) showed an important application in inhibiting tumor growth by producing the highly toxic hydroxyl radical (·OH), but insufficient hydrogen peroxide (H₂O₂) and overexpressed glutathione (GSH) limited its application. Herein, by integrating photothermal therapy (PTT) and CDT, a new kind of mesoporous polydopamine (MPDA)-based cascade-reaction nanoplatform (MPDA@AuNPs-Cu) was designed for enhanced antitumor therapy, in which ultrasmall gold nanoparticles (AuNPs) with glucose oxidase (GOx)-like activity were deposited on MPDA for providing H₂O₂, and Cu²⁺ was chelated for GSH-responsive Fenton-like reaction. It was demonstrated that the MPDA@AuNPs-Cu nanoprobe showed high photothermal conversion efficiency and excellent biocompatibility. Moreover, the MPDA@AuNPs-Cu nanoprobe exhibited strong ·OH generation because of H₂O₂ self-generation and photothermal stimulation. Importantly, compared with MPDA-Cu, MPDA@AuNPs-Cu exhibited enhanced in vitro and in vivo CDT/PTT performance, by which the tumor growth was completely inhibited, achieving TME-responsive antitumor efficacy.24:T51f,Chemodynamic therapy (CDT) has shown potential for important applications in tumor precision therapy, but insufficient endogenous hydrogen peroxide (H₂O₂), overexpressed glutathione (GSH) and a weak Fenton-reaction rate greatly reduced the efficacy of CDT. Herein, a metal-organic framework (MOF) based bimetallic nanoprobe with self-supplying H₂O₂ was developed for enhancing CDT with triple amplification, in which ultrasmall gold nanoparticles (AuNPs) were deposited on Co-based MOFs (ZIF-67), and manganese dioxide (MnO₂) nanoshells were coated to form a ZIF-67@AuNPs@MnO₂ nanoprobe. In the tumor microenvironment, MnO₂ depleted overexpressed GSH to produce Mn²⁺, and the bimetallic Co²⁺/Mn²⁺ nanoprobe accelerated the Fenton-like reaction rate. Moreover, by catalyzing

#	Concept	H-Index	Publications	Citations
1	Engineering	2	2	50
2	Biomedical Engineering	2	2	50
3	Medicine	1	1	17
4	Chemical Engineering	1	1	33
5	Chemistry	1	1	33

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