Brian P. H. Metzger

Selection on noise constrains variation in a eukaryotic promoter

Brian P. H. Metzger, D Yuan, Jonathan D. Gruber et al. · Nature · 2015 · 172 citations

Life Sciences, Genetics, Molecular Biology +14

A hydrophobic ratchet entrenches molecular complexes

Georg Hochberg, Yang Liu, Erik G. Marklund et al. · Nature · 2020 · 143 citations · Full text

Natural Sciences, Biochemistry, Biophysics +12

Contrasting Frequencies and Effects of<i>cis</i>- and<i>trans</i>-Regulatory Mutations Affecting Gene Expression

Brian P. H. Metzger, Fabien Duveau, D Yuan et al. · Molecular Biology and Evolution · 2016 · 130 citations · Full text

Life Sciences, Biology, Genetics +17

Epistatic drift causes gradual decay of predictability in protein evolution

Yeonwoo Park, Brian P. H. Metzger, Joseph W. Thornton · Science · 2022 · 129 citations · Full text

Life Sciences, Biology, Evolutionary Biology +17

Evolutionary Dynamics of Regulatory Changes Underlying Gene Expression Divergence among Saccharomyces Species

Brian P. H. Metzger, Patricia J. Wittkopp, Joseph D. Coolon · Genome Biology and Evolution · 2017 · 98 citations · Full text

Life Sciences, Evolutionary Biology, Genetics +17