Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death

Wissal El-Assaad, Jean Buteau, Marie‐Line Peyot, +7

Endocrinology

Saturated Fatty Acid-induced Apoptosis in MDA-MB-231 Breast Cancer Cells

Serge Hardy, Wissal El-Assaad, Ewa Przybytkowski, +3

Journal of Biological Chemistry

Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects.

Serge Hardy, Yves Langelier, Marc Prentki

PubMed

Opposite EffectsSaturated Ffa PalmitateChemoprevention StrategyApoptosisCell Death +18

Oleate Promotes the Proliferation of Breast Cancer Cells via the G Protein-coupled Receptor GPR40

Serge Hardy, Geneviève St‐Onge, Érik Joly, +2

Journal of Biological Chemistry

The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis

Serge Hardy, Noriko Uetani, Nau Nau Wong, +6

Oncogene

Signal TransductionSignaling PathwayBiochemistryNatural SciencesReceptor Tyrosine Kinase +8

Casein Kinase II Increases the Transcriptional Activities of MRF4 and MyoD Independently of Their Direct Phosphorylation

Sally Johnson, Xueyan Wang, Serge Hardy, +2

Molecular and Cellular Biology

Molecular BiologyMrf-e Protein HeterodimerTranscriptional RegulationSignaling PathwayTranscriptional Activities +17

PTP1B Is an Androgen Receptor–Regulated Phosphatase That Promotes the Progression of Prostate Cancer

Laurent Lessard, David P. Labbé, Geneviève Deblois, +7

Cancer Research

Androgen ReceptorTumor BiologyTranscriptional RegulationSignaling PathwayReceptor Tyrosine Kinase +15

Overexpression of the Protein Tyrosine Phosphatase PRL-2 Correlates with Breast Tumor Formation and Progression

Serge Hardy, Nau Nau Wong, William J. Muller, +2

Cancer Research

Breast OncologyCancer BiologyTumor BiologyBreast Cancer ProgressionSignaling Pathway +14

Fibroblast Growth Factor Inhibits MRF4 Activity Independently of the Phosphorylation Status of a Conserved Threonine Residue within the DNA-Binding Domain

Serge Hardy, Yanfeng Kong, Stephen F. Konieczny

Molecular and Cellular Biology

Molecular BiologyPhosphorylation StatusCytoskeletonMrf4 ProteinsCellular Physiology +18

Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2

Paula Giménez-Mascarell, Iker Oyenarte, Serge Hardy, +12

Journal of Biological Chemistry

Magnesium Transporter Cnnm2Signal TransductionBiochemistryPhosphatase Prl-1Membrane Transport +9