Timothy F. Shay

Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden et al. · Nature Nanotechnology · 2023 · 124 citations · Full text

Pharmacy, Neurobiology, Neuroscience +17

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

Xinhong Chen, Damien A. Wolfe, Dhanesh Sivadasan Bindu et al. · Nature Communications · 2023 · 92 citations · Full text

Pharmacy, Neurobiology, Neuroscience +17

Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors

Timothy F. Shay, Erin E. Sullivan, Xiaozhe Ding et al. · Science Advances · 2023 · 69 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

Timothy F. Shay, Seongmin Jang, Tyler J. Brittain et al. · Nature Communications · 2024 · 21 citations · Full text

Life Sciences, Cell Biology, Immunology +13

Adeno-associated viral tools to trace neural development and connectivity across amphibians

Eliza C.B. Jaeger, David Vijatovic, Astrid Deryckere et al. · Developmental Cell · 2024 · 16 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17