Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes

Jiaming Hu, Jinyi Zhou, Jinting Wu, +10

Journal of Ethnopharmacology

InflammationRheumatologyMusculoskeletal ResearchImmunologyCartilage Degeneration +7

Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling

Huan Yu, Sai Yao, Chengchong Zhou, +8

Journal of Ethnopharmacology

InflammationRheumatologyAnti-inflammatoryMedicineOsteoarthritic Development +8

Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth

Fangda Fu, Ronghua Bao, Sai Yao, +16

Scientific Reports

Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling

Yuying Chen, Chengcong Zhou, Yishan Bian, +11

Ecotoxicology and Environmental Safety

Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration

Huihao Zhang, Sai Yao, Zhiguo Zhang, +18

Drug Design Development and Therapy

Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway

Chengcong Zhou, Sai Yao, Fangda Fu, +13

Frontiers in Pharmacology

Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway

Xuyan Zhao, Huan Luo, Sai Yao, +4

The Science of The Total Environment

Atrazine ExposureCardiomyopathyCardiovascular DiseaseMedicinePhysiology +9

Integration of Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanisms of Zhuanggu Busui Formula Against Osteoporosis

Huihao Zhang, Chengcong Zhou, Zhiguo Zhang, +17

Frontiers in Endocrinology

Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytes

Quan Chen, Huan Luo, Chengcong Zhou, +13

PLoS ONE

Aav VectorImmunologyPathologyEfficient TransductionOrthopaedic Surgery +18

Biomechanical, histologic, and molecular characteristics of graft-tunnel healing in a murine modified ACL reconstruction model

Huan Yu, Fangda Fu, Sai Yao, +7

Journal of Orthopaedic Translation