Nicole A. Seebacher

Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo

David B. Lovejoy, Danae M. Sharp, Nicole A. Seebacher et al. · Journal of Medicinal Chemistry · 2012 · 196 citations

Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)

Patric J. Jansson, Tetsuo Yamagishi, Akanksha Arvind et al. · Journal of Biological Chemistry · 2015 · 127 citations · Full text

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

Nicole A. Seebacher, Des R. Richardson, Patric J. Jansson · Cell Death and Disease · 2016 · 106 citations · Full text

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma

Hangzhan Ma, Nicole A. Seebacher, Francis J. Hornicek et al. · EBioMedicine · 2018 · 95 citations · Full text

Glucose modulation induces reactive oxygen species and increases <scp>P</scp>‐glycoprotein‐mediated multidrug resistance to chemotherapeutics

Nicole A. Seebacher, Des R. Richardson, Patric J. Jansson · British Journal of Pharmacology · 2015 · 61 citations · Full text