Tatyana A. Shelkovnikova

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

Jelena Scekic‐Zahirovic, Oliver Sendscheid, Hajer El Oussini et al. · The EMBO Journal · 2016 · 242 citations · Full text

Life Sciences, Genetics, Neuroscience +17

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

Haiyan An, Lucy Skelt, Antonietta Notaro et al. · Acta Neuropathologica Communications · 2019 · 153 citations · Full text

Life Sciences, Genetics, Neuroscience +13

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

Tatyana A. Shelkovnikova, Hannah K. Robinson, Claire Troakes et al. · Human Molecular Genetics · 2013 · 145 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice

Tatyana A. Shelkovnikova, Owen M. Peters, Alexey V. Deykin et al. · Journal of Biological Chemistry · 2013 · 119 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An et al. · Molecular Neurodegeneration · 2018 · 111 citations · Full text

Life Sciences, Neurology, Neuroscience +17