Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine

Amir Levine, Yan-You Huang, Bettina Drisaldi, +7

Science Translational Medicine

CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum

Amir Levine, Zhonghui Guan, Ángel Barco, +3

Proceedings of the National Academy of Sciences

Mouse StriatumCreb-binding ProteinNeurotransmitterSocial SciencesCbp Gene +16

Chromatin remodeling — a novel strategy to control excessive alcohol drinking

Vincent Warnault, Emmanuel Darcq, Amir Levine, +2

Translational Psychiatry

Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment

Amir Levine, Trent R. Worrell, Ross Zimnisky, +1

Neurobiology of Disease

PsychopathologyHistone Deacetylase ExpressionPsychiatryStress HormoneStress +13

Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer’s disease: novel methodology and clinical proof of concept

Erez Eitan, Tricia A. Thornton‐Wells, Katya Elgart, +7

Extracellular Vesicles and Circulating Nucleic Acids

D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus

Yan-You Huang, Amir Levine, Denise B. Kandel, +4

Learning & Memory

NeuropsychologyGateway EffectPsychopharmacologyD1/d5 ReceptorsNeurotransmission +19

A multi-animal tracker for studying complex behaviors

Eyal Itskovits, Amir Levine, Ehud Cohen, +1

BMC Biology

WorMachine: machine learning-based phenotypic analysis tool for worms

Adam Hakim, Yael Mor, Itai Antoine Toker, +4

BMC Biology

Early adolescent nicotine exposure affects later-life cocaine reward in mice

Mai Alajaji, Matthew F. Lazenka, Dena Kota, +7

Neuropharmacology

Substance AbuseBehavioral SciencesSubstance UseBehavioral NeuroscienceAddiction +8

Nicotine primes the effect of cocaine on the induction of LTP in the amygdala

Yan-You Huang, Denise B. Kandel, Eric R. Kandel, +1

Neuropharmacology

Psychoactive DrugNeurophysiologyAddictionMedicineNicotine +6