A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

Klaus Bønnelykke, Patrick Sleiman, Kasper Nielsen, +33

Nature Genetics

AsthmaImmunogeneticsSevere ExacerbationsInflammatory Lung DiseaseGenetics +7

Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats

Matthew C. Wright, Razo Issa, David E. Smart, +6

Gastroenterology

InflammationFibrosisLiver FibrosisHepatologyLiver Physiology +11

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

Mark G. Jones, Orestis G. Andriotis, James Roberts, +31

eLife

Tissue EngineeringEngineeringInflammatory Lung DiseaseLung InflammationTissue Stiffness +20

Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury

Fiona Oakley, Jelena Mann, Sarah Nailard, +8

American Journal Of Pathology

InflammationFibrogenic ResponsesFibrosisInflammatory DiseaseImmune Regulation +9

JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells

David E. Smart, Karen J. Vincent, Michael J.P. Arthur, +4

Journal of Biological Chemistry

Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-κB, AP-1 and Sp1

Terumi Takahra, David E. Smart, Fiona Oakley, +1

The International Journal of Biochemistry & Cell Biology

Transcriptional RegulationFibrosisCell RegulationImmunologyMyofibroblast Mmp-9 Transcription +8

Control of the Tissue Inhibitor of Metalloproteinases–1 Promoter in Culture–Activated Rat Hepatic Stellate Cells: Regulation by Activator Protein–1 Dna Binding Proteins

Mathias Bähr, Karen J. Vincent, Michael J.P. Arthur, +7

Hepatology

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis

Franco Conforti, Elizabeth R. Davies, Claire Calderwood, +19

Oncotarget

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products

Orestis G. Andriotis, Kareem Elsayad, David E. Smart, +3

Biomedical Optics Express

Tissue EngineeringCollagen FibrilsNormal AgeingEngineeringNanomechanical Changes +14

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation

David E. Smart, Karen Green, Fiona Oakley, +6

Hepatology