Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Sarah A. Tersey, Yurika Nishiki, Andrew T. Templin, +7

Diabetes

ImmunologyImmune RegulationEr StressInsulin SignalingImmune Dysregulation +20

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Masayuki Hatanaka, Bernhard Maier, Emily K. Sims, +4

Diabetes

Molecular RegulationFree Fatty AcidsMrna TranslationTotal RnaCellular Physiology +21

Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells

Chong Wee Liew, Andrew T. Templin, Jeffrey C. Raum, +13

Proceedings of the National Academy of Sciences

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets

Daniel T. Meier, Leon Entrup, Andrew T. Templin, +5

Diabetologia

Knockout MouseIslet TransplantationAlzheimer's DiseaseWild-type HiappS20g Substitution +6

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling

Andrew T. Templin, Bernhard Maier, Yurika Nishiki, +2

Cell Cycle

ImmunologyAmino Acid HypusineDhs Knockout MiceInsulin SignalingOxidative Stress +19

Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet β-Cells

Yurika Nishiki, Adeola F. Adewola, Masayuki Hatanaka, +3

Molecular Endocrinology

ImmunologyP38 MapkInsulin SignalingOxidative StressInflammation +18

Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet

Li Lin, Rashmita Basu, Debolina Chatterjee, +3

Scientific Reports

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Andrew T. Templin, Tanya Samarasekera, Daniel T. Meier, +7

Diabetes

Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice

Joseph Castillo, Alfred C. Aplin, Daryl J. Hackney, +8

Diabetologia

InflammationAutoimmune DiseaseMedicineDiabetesImmunology +9

RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity

Christopher Contreras, Noyonika Mukherjee, Renato C.S. Branco, +6

Molecular Metabolism