Dexmedetomidine alleviates cognitive impairment by promoting hippocampal neurogenesis via BDNF/TrkB/CREB signaling pathway in hypoxic–ischemic neonatal rats

Andi Chen, Jianjie Wei, Yongxin Huang, +10

CNS Neuroscience & Therapeutics

Dexmedetomidine Attenuates Apoptosis and Neurological Deficits by Modulating Neuronal NADPH Oxidase 2-Derived Oxidative Stress in Neonates Following Hypoxic Brain Injury

Xiaohui Chen, Dongtai Chen, Pinzhong Chen, +5

Antioxidants

Dexmedetomidine alleviates olfactory cognitive dysfunction by promoting neurogenesis in the subventricular zone of hypoxic-ischemic neonatal rats

Andi Chen, Jianhui Deng, Jianjie Wei, +7

Frontiers in Pharmacology

Gut microbiome-derived lipopolysaccharides aggravate cognitive impairment via TLR4-mediated inflammatory signaling in neonatal rats following hypoxic-ischemic brain damage

Jianjie Wei, Andi Chen, Dongqin Huang, +9

Brain Behavior and Immunity

Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats

Haitao Qian, Andi Chen, Daoyi Lin, +7

International Immunopharmacology

Gut microbial dysbiosis exacerbates long-term cognitive impairments by promoting intestinal dysfunction and neuroinflammation following neonatal hypoxia-ischemia

Andi Chen, C Teng, Jianjie Wei, +8

Gut Microbes