3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2<i>H</i>-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation:  A Dual Function Lead for Alzheimer's Disease Therapy

Lorna Piazzi, Angela Rampa, Alessandra Bisi, +7

Journal of Medicinal Chemistry

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

Lorna Piazzi, Andrea Cavalli, Francesco Colizzi, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNeurodegenerative DiseasesAlzheimer's DiseaseBace1 InhibitorsMedicine +9

Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, β Amyloid Aggregation, and Aβ Neurotoxicity

Stefano Rizzo, Céline Rivière, Lorna Piazzi, +8

Journal of Medicinal Chemistry

SAR of 9-Amino-1,2,3,4-tetrahydroacridine-Based Acetylcholinesterase Inhibitors:  Synthesis, Enzyme Inhibitory Activity, QSAR, and Structure-Based CoMFA of Tacrine Analogues

Maurizio Recanatini, Andrea Cavalli, Federica Belluti, +8

Journal of Medicinal Chemistry

Lead Optimization Providing a Series of Flavone Derivatives as Potent Nonsteroidal Inhibitors of the Cytochrome P450 Aromatase Enzyme

Silvia Gobbi, Andrea Cavalli, Angela Rampa, +6

Journal of Medicinal Chemistry

Flavone 1Comfa ModelBioorganic ChemistryPotent Nonsteroidal InhibitorsLead Identification +16

Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238

Stefano Rizzo, Manuela Bartolini, Luisa Ceccarini, +6

Bioorganic & Medicinal Chemistry

Molecular PharmacologyNeurodegenerative DiseasesAlzheimer's DiseaseNovel TherapyMedicine +8

Cholinesterase Inhibitors:  Xanthostigmine Derivatives Blocking the Acetylcholinesterase-Induced β-Amyloid Aggregation

Federica Belluti, Angela Rampa, Lorna Piazzi, +7

Journal of Medicinal Chemistry

Extensive SAR and Computational Studies of 3-{4-[(Benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2<i>H</i>-2-chromenone (AP2238) Derivatives

Lorna Piazzi, Andrea Cavalli, Federica Belluti, +7

Journal of Medicinal Chemistry

Enantioselective Nonsteroidal Aromatase Inhibitors Identified through a Multidisciplinary Medicinal Chemistry Approach

Andrea Cavalli, Alessandra Bisi, Carlo Bertucci, +10

Journal of Medicinal Chemistry

Imidazolylmethylbenzophenones as Highly Potent Aromatase Inhibitors

Silvia Gobbi, Andrea Cavalli, Matthias Negri, +6

Journal of Medicinal Chemistry