Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Barbara Bosch, Michael A. DeJesus, Nicholas C. Poulton, +12

Cell

Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes

Eachan O. Johnson, Emily LaVerriere, Emma Office, +41

Nature

Medicinal ChemistryAntimicrobial Drug DiscoveryPulmonary TuberculosisMedicineTuberculosis Prevention +7

Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection

Alexandre Gouzy, Gerald Larrouy‐Maumus, Daria Bottai, +13

PLoS Pathogens

Microbial PathogensBacteriologyImmunologyMolecular BiologyIntracellular Pathogen +17

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

Jee-Hyun Kim, Kathryn O’Brien, Ritu Sharma, +11

Proceedings of the National Academy of Sciences

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

Wěi Li, Andrés Obregón‐Henao, Joshua B. Wallach, +5

Antimicrobial Agents and Chemotherapy

Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase

Jeehyun Kim, Jun-Rong Wei, Joshua B. Wallach, +3

Nucleic Acids Research

BacteriologyProteasomeMolecular BiologyProtein TagBacterial Pathogens +16

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

Kan Lin, Kathryn O’Brien, Carolina Trujillo, +4

PLoS Pathogens

Minor RoleCell DeathThiol Redox HomeostasisMtb Pathogenesis RemainRedox Biology +14

Discovery and Structure–Activity-Relationship Study of <i>N</i>-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-<scp>d</scp>-ribose 2′-Oxidase

Sangmi Oh, Yumi Park, Curtis A. Engelhart, +13

Journal of Medicinal Chemistry

Depletion of the DarG antitoxin in <i>Mycobacterium tuberculosis</i> triggers the DNA‐damage response and leads to cell death

Anisha Zaveri, Ruojun Wang, Laure Botella, +8

Molecular Microbiology

ToxinologyMicrobial PathogensCell DeathMolecular BiologyDarg Antitoxin +16

Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models

Xin Wang, Hong-Wei Su, Joshua B. Wallach, +22

Nature Microbiology