Mary Ellen Simcox

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

A.P. Turnbull, Stephanos Ioannidis, Wojciech Krajewski et al. · Nature · 2017 · 448 citations

Drug Target, Usp7 Inhibition, Medicine +4

RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models

Hong Yang, Brian Higgins, Kenneth Kolinsky et al. · Cancer Research · 2010 · 400 citations

Melanoma Cell Lines, Phase Ii, Medicine +15

Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer

Hong Yang, Brian Higgins, Kenneth Kolinsky et al. · Cancer Research · 2011 · 214 citations · Full text

Antitumor Activity, Cancer Biology, Tumor Biology +17

Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation

Fei Su, William D. Bradley, Qiongqing Wang et al. · Cancer Research · 2011 · 177 citations

Cancer Biology, Tumor Biology, Signaling Pathway +16

CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies

Steven N. Quayle, Natasha Girgis, Dharma R. Thapa et al. · Clinical Cancer Research · 2020 · 56 citations · Full text