Seth Huggins

The Pharmaceutical Drying Unit Operation: An Industry Perspective on Advancing the Science and Development Approach for Scale-Up and Technology Transfer

Edward W. Conder, Andrew Cosbie, John Gaertner et al. · Organic Process Research & Development · 2017 · 57 citations

Pharmacy, Materials Engineering, Pharmaceutics +15

A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation

Elçin Içten, Andrew J. Maloney, Matthew G. Beaver et al. · Organic Process Research & Development · 2020 · 36 citations

Engineering, Chemical Engineering, Process Control +14

A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration

Andrew J. Maloney, Elçin Içten, Gerard Capellades et al. · Organic Process Research & Development · 2020 · 32 citations

Engineering, Chemical Engineering, Manufacturing Engineering +17

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS^G12C Inhibitor

Liang Zhang, Daniel J. Griffin, Matthew G. Beaver et al. · Organic Process Research & Development · 2022 · 31 citations

Pharmacy, Chemical Engineering, Medicinal Chemistry +14

A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process

Elçin Içten, Andrew J. Maloney, Matthew G. Beaver et al. · Organic Process Research & Development · 2020 · 24 citations

Engineering, Chemical Engineering, Pharmaceutical Manufacturing +14