Nicola Trendel

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

Melissa Lever, Hong-Sheng Lim, Philipp Krüger et al. · Proceedings of the National Academy of Sciences · 2016 · 94 citations · Full text

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

Wei Yang, Weiling Pan, Shuokai Chen et al. · Nature Structural & Molecular Biology · 2017 · 60 citations

Dynamic Regulation, Proteinlipid Interaction, Signal Transduction +11

Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses

Enas Abu‐Shah, Nicola Trendel, Philipp Krüger et al. · The Journal of Immunology · 2020 · 31 citations · Full text

Perfect adaptation of CD8 ⁺ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation

Nicola Trendel, Philipp Krüger, Stephanie Gaglione et al. · Science Signaling · 2021 · 30 citations · Full text

Antigen Input, T Cell Responses, Immune Activation +20

Cooperative Clustering Digitizes Biochemical Signaling and Enhances its Fidelity

Edward Roob, Nicola Trendel, Pieter Rein ten Wolde et al. · Biophysical Journal · 2016 · 29 citations · Full text

Metabolic Network, Engineering, Natural Sciences +7