Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

Karen Castillo, Melissa Nassif, Vicente Valenzuela, +6

Autophagy

MitophagyCell DeathCell AutophagyAutophagyNeurology +14

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

Fabiola Rojas, Nicole Cortés, Sebastián Abarzúa, +2

Frontiers in Cellular Neuroscience

Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

Elsa Fritz, Pamela Izaurieta, Alexandra Weiss, +7

Journal of Neurophysiology

Calcium TransientsAmyotrophic Lateral SclerosisMolecular PhysiologyMolecular NeuroscienceNeurophysiology +13

Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

Fabiola Rojas, David González, Nicole Cortés, +9

Frontiers in Cellular Neuroscience

Als-expressing AstrocytesTyrosine KinaseApoptosisCell DeathC-abl Signaling +16

Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

Cristián Arredondo, Carolina Cefaliello, Agnieszka Dyrda, +34

Neuron

Excessive ReleaseAmyotrophic Lateral SclerosisNeurophysiologyInorganic PolyphosphateAls/ftd Astrocytes +8

αVβ3 Integrin regulates astrocyte reactivity

Raúl Lagos‐Cabré, Álvaro Álvarez, Milene Kong, +11

Journal of Neuroinflammation

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

Nur Jury, Sebastián Abarzúa, Iván Darío Parrado Díaz, +12

Clinical Epigenetics

Chronic infusion of SOD1^G93A astrocyte‐secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats

Uri Nimrod Ramírez-Jarquín, Fabiola Rojas, Brigitte van Zundert, +1

Journal of Cellular Physiology

Higher adenoma recurrence rate after left- versus right-sided colectomy for colon cancer

Lorenzo Fuccio, Cristiano Spada, Leonardo Frazzoni, +9

Gastrointestinal Endoscopy

Surgical OncologyGastrointestinal OncologyColorectal SurgeryCancer RecurrenceSurgical Pathology +7

Influence of K-ras status and anti-tumour treatments on complications due to colorectal self-expandable metallic stents: A retrospective multicentre study

Lorenzo Fuccio, Loredana Correale, Alberto Arezzo, +26

Digestive and Liver Disease

Colorectal SurgeryMedicineK-ras StatusVascular SurgeryLumen-apposing Metal Stent +5