International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Ksenia Blinova, Qianyu Dang, Daniel Millard, +19

Cell Reports

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

Hiroyuki Ando, Takashi Yoshinaga, Wataru Yamamoto, +16

Journal of Pharmacological and Toxicological Methods

Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes

Keiichi Asakura, Seiji Hayashi, Atsuko Ojima, +12

Journal of Pharmacological and Toxicological Methods

Differential nociceptive responses in mice lacking the α1B subunit of N-type Ca2+ channels

Shinji Hatakeyama, Minoru Wakamori, Mitsuhiro Ino, +11

Neuroreport

Functional disorders of the sympathetic nervous system in mice lacking the α _1B subunit (Ca _v 2.2) of N-type calcium channels

Mitsuhiro Ino, Takashi Yoshinaga, Minoru Wakamori, +15

Proceedings of the National Academy of Sciences

N-type Voltage-dependent CaSynaptic TransmissionNeurotransmitterNeurotransmissionPeripheral Nerves +17

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

Junichi Okada, Takashi Yoshinaga, Junko Kurokawa, +5

Science Advances

Drug SafetyHeart FailureDrug-induced Arrhythmogenic RiskPatch ClampCardiovascular Disease +13

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential

Wataru Yamamoto, Keiichi Asakura, Hiroyuki Ando, +14

PLoS ONE

Cardiac MuscleHeart FailureEngineeringBiomedical EngineeringCardiovascular Function +17

Study of neuroprotection of donepezil, a therapy for Alzheimer's disease

Shigeru Akasofu, M. Kimura, Takashi Kosasa, +2

Chemico-Biological Interactions

Alzheimer's DiseaseMedicineDementiaNeuropharmacologyFrontotemporal Dementia +8

Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons.

Manabu Kuwada, Takashi Teramoto, Kumiko Yoshizawa Kumagaye, +7

Molecular Pharmacology

Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell–Derived Cardiomyocyte Sheet: Multi-site Validation Study

Yuji Nakamura, Junko Matsuo, Norimasa Miyamoto, +6

Journal of Pharmacological Sciences