Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

Louis S. Ates, Roy Ummels, Susanna Commandeur, +13

PLoS Genetics

Outer Membrane PermeabilityProtein SecretionBacteriologyMolecular BiologyBacterial Pathogenesis +16

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis

Louis S. Ates, Anzaan Dippenaar, Roy Ummels, +15

Nature Microbiology

Medical MicrobiologyPulmonary TuberculosisMycobacterium TuberculosisPathogenesisMolecular Biology +3

Type VII Secretion: A Highly Versatile Secretion System

Louis S. Ates, Edith N. G. Houben, Wilbert Bitter

Microbiology Spectrum

Protein SecretionSignal TransductionVirulence FactorType Vii SecretionPathogenesis +12

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10

Louis S. Ates, Aniek D. van der Woude, Jovanka Bestebroer, +9

PLoS Pathogens

BacteriologyImmunologyBacteriophageCytoskeletonBacterial Pathogenesis +16

Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity

Louis S. Ates, Anzaan Dippenaar, Fadel Sayes, +9

Genome Biology and Evolution

Protein SecretionMycobacterium Tuberculosis ComplexImmunologyPhylogenetic AnalysisDrug Resistance +16

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Louis S. Ates, Fadel Sayes, Wafa Frigui, +8

PLoS Pathogens

Protein SecretionMicrobial PathogensImmunologyImmunodominanceMolecular Biology +18

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

Fadel Sayes, Catherine Blanc, Louis S. Ates, +14

Cell Reports

Comparison of in vitro activities of tigecycline, doxycycline, and tetracycline against the spirochete Borrelia burgdorferi

Louis S. Ates, Christa Hanssen-Hübner, Douglas E. Norris, +3

Ticks and Tick-borne Diseases

Antiparasitic AgentDrug ResistanceSpirochete Borrelia BurgdorferiPharmacologyTick-borne Disease +1

Separate signaling events control TCR downregulation and T cell activation in primary human T cells

Lieve E. H. van der Donk, Louis S. Ates, Jet van der Spek, +3

Immunity Inflammation and Disease

Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts

Mickael Orgeur, Wafa Frigui, Alexandre Pawlik, +8

Microbial Genomics