Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis

Yufeng Chen, Marthandam Asokan Shibu, Ming-Jen Fan, +8

The Journal of Nutritional Biochemistry

Cardiac FunctionCardiomyopathyHeart FailureCardiac MuscleMedicine +9

Protective effects of luteolin against oxidative stress and mitochondrial dysfunction in endothelial cells

Hsiu‐I Chen, Wei‐Syun Hu, Meng-Yu Hung, +8

Nutrition Metabolism and Cardiovascular Diseases

InflammationOxysterolEndothelial CellsMitochondrial DysfunctionMedicine +10

Tetramethylpyrazine Ameliorated Hypoxia-Induced Myocardial Cell Apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 Inhibition to Upregulate PI3K/Akt Survival Signaling

Kuan‐Ho Lin, Wei‐Wen Kuo, Ai-Zhi Jiang, +7

Cellular Physiology and Biochemistry

Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice

You-Liang Hsieh, Marthandam Asokan Shibu, Chong‐Kuei Lii, +7

Journal of Ethnopharmacology

Cardiovascular ToxicityAndrographis Paniculata ExtractCardiovascular DiseaseMedicinePhysiology +7

Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression

Chih-Chung Feng, Chien‐Chung Lin, Yi-Ping Lai, +7

Growth Factors

Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury

Kuan‐Ho Lin, Chien-Yu Li, Yuan‐Man Hsu, +6

Food and Chemical Toxicology

InflammationNgf-differentiated Pc12 CellsCytokineAnti-inflammatoryMedicine +9

GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt‐mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway

Bih‐Cheng Chen, Meng‐Yu Hung, Hsueh‐Fang Wang, +7

Environmental Toxicology

Cardiovascular ToxicityHypertensionHeart FailureCardiomyopathyCardiovascular Disease +12

NFIL3 Suppresses Hypoxia‐induced Apoptotic Cell Death by Targeting the Insulin‐like Growth Factor 2 Receptor

Kuan‐Ho Lin, Chia‐Hua Kuo, Wei‐Wen Kuo, +7

Journal of Cellular Biochemistry

Cardiac MuscleApoptosisImmunologyCell DeathInsulin Signaling +15

Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Kuan‐Ho Lin, Marthandam Asokan Shibu, Wei‐Wen Kuo, +7

Environmental Toxicology

CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death

Wei-Kung Chen, Wei‐Wen Kuo, Dennis Jine‐Yuan Hsieh, +7

International Journal of Molecular Sciences

Cell DeathMetabolic RemodelingCellular PhysiologyOxidative StressTranscriptional Regulation +14