Doris N. Luchini

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

Alan P. Kozikowski, Subhasish Tapadar, Doris N. Luchini et al. · Journal of Medicinal Chemistry · 2008 · 187 citations · Full text

From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells

Irina N. Gaisina, Franck Gallier, Andrei V. Ougolkov et al. · Journal of Medicinal Chemistry · 2009 · 124 citations · Full text

Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II

Lisa M. Oppegard, Andrei V. Ougolkov, Doris N. Luchini et al. · European Journal of Pharmacology · 2008 · 69 citations · Full text

Medicinal Chemistry, Pancreatic Cancer, Biochemistry +9

Asef2 Functions as a Cdc42 Exchange Factor and Is Stimulated by the Release of an Autoinhibitory Module from a Concealed C-Terminal Activation Element

Michael J. Hamann, Casey M. Lubking, Doris N. Luchini et al. · Molecular and Cellular Biology · 2006 · 53 citations · Full text

Cdc42 Exchange Factor, Asef2 Functions, Molecular Biology +20

Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity

Subhasish Tapadar, Rong He, Doris N. Luchini et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 39 citations · Full text

Hdac Inhibitors, Biochemistry, Medicine +10