Simone Mester

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Stian Foss, Siri Aastedatter Sakya, Leire Aguinagalde et al. · Nature Communications · 2024 · 73 citations · Full text

Pharmacy, Biotechnology, Immunology +17

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn<i>in vitro</i>and<i>in vivo</i>

Simone Mester, Mitchell Evers, Saskia Meyer et al. · mAbs · 2021 · 53 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

Algirdas Grevys, Rahel Frick, Simone Mester et al. · iScience · 2022 · 51 citations · Full text

Pharmacy, Biochemistry, Pharmacokinetics +17

Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells

Marta Lustig, Chilam Chan, J.H. Marco Jansen et al. · Frontiers in Immunology · 2023 · 40 citations · Full text

Medicine, Immunology, Oncology +17

Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Torleif Tollefsrud Gjølberg, Rahel Frick, Simone Mester et al. · Communications Biology · 2022 · 32 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +16