Cynthia M. June

Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam

Kip-Chumba J. Kaitany, Neil V. Klinger, Cynthia M. June et al. · Antimicrobial Agents and Chemotherapy · 2013 · 90 citations · Full text

Bioorganic Chemistry, Mechanistic Basis, Antimicrobial Chemotherapy +16

Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D β-Lactamases from <i>Acinetobacter baumannii</i>

Joshua M. Mitchell, Jozlyn R. Clasman, Cynthia M. June et al. · Biochemistry · 2015 · 38 citations · Full text

Antimicrobial Chemotherapy, Antibiotic Resistance, Drug Resistance +20

The structure of a doripenem‐bound OXA‐51 class D β‐lactamase variant with enhanced carbapenemase activity

Cynthia M. June, Taylor J. Muckenthaler, Emma C. Schroder et al. · Protein Science · 2016 · 38 citations · Full text

Indole Ring, Biochemistry, Active Site Substitutions +12

Structural Origins of Oxacillinase Specificity in Class D β-Lactamases

Cynthia M. June, B.C. Vallier, Robert A. Bonomo et al. · Antimicrobial Agents and Chemotherapy · 2013 · 36 citations · Full text

Bioorganic Chemistry, Chemical Biology, Bacterial Pathogens +19

Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems

Emma C. Schroder, Zachary Klamer, Ayşegül Saral et al. · Antimicrobial Agents and Chemotherapy · 2016 · 22 citations · Full text

Antimicrobial Chemotherapy, Clinical Variants, Analytical Ultracentrifugation +24