Cora O’Neill

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Aileen M. Moloney, Rebecca J. Griffin, Suzanne Timmons et al. · Neurobiology of Aging · 2008 · 756 citations

Neurodegenerative Diseases, Alzheimer's Disease, Insulin Signalling +11

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

Rebecca J. Griffin, Aileen M. Moloney, Mary Kelliher et al. · Journal of Neurochemistry · 2005 · 453 citations

Cell Death, Neurochemical Biomarkers, Social Sciences +20

Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis

Stefanie Grabrucker, Moira Marizzoni, Edina Silajdžić et al. · Brain · 2023 · 192 citations · Full text

Dysbiosis, Host-microbe Interactions, Gut Microbiota +20

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

Caitríona M. Long-Smith, Sean Manning, Paula L. McClean et al. · NeuroMolecular Medicine · 2012 · 154 citations

Neurodegenerative Diseases, Alzheimer's Disease, Biochemistry +11

Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and β-amyloid pathologies

Mary Kelliher, Johan Fastbom, Richard F. Cowburn et al. · Neuroscience · 1999 · 147 citations

Neurodegenerative Diseases, β-Amyloid Pathologies, Molecular Neuroscience +12