.alpha.-Hydroxy esters as chiral auxiliaries in asymmetric cyclopropanations by rhodium(II)-stabilized vinylcarbenoids

Huw M. L. Davies, Nicholas Huby, William R. Cantrell, +1

Journal of the American Chemical Society

Asymmetric CyclopropanationsEngineering.Alpha.-hydroxy EstersChiral AuxiliariesDonut Icon +10

Enantioselective Synthesis of Functionalized Tropanes by Rhodium(II) Carboxylate-Catalyzed Decomposition of Vinyldiazomethanes in the Presence of Pyrroles

Huw M. L. Davies, Julius J. Matasi, L. Mark Hodges, +4

The Journal of Organic Chemistry

Chemical EngineeringEngineeringNatural SciencesDiversity-oriented SynthesisChiral Auxiliary +12

Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure−Activity Relationships, and X-ray Crystal Structures

David Bolin, Amy L. Swain, Ramakanth Sarabu, +24

Journal of Medicinal Chemistry

Synthesis of 2.beta.-Acyl-3.beta.-aryl-8-azabicyclo[3.2.1]octanes and Their Binding Affinities at Dopamine and Serotonin Transport Sites in Rat Striatum and Frontal Cortex

Huw M. L. Davies, Elie Saikali, Nicholas Huby, +3

Journal of Medicinal Chemistry

Homoanatoxin: A potent analogue of anatoxin-a

Susan Wonnacott, Karen L. Swanson, Edson X. Albuquerque, +3

Biochemical Pharmacology

Potent AnalogueBiochemistryMedicineMechanism Of ActionPharmacology +1

Peptidomimetic compounds that inhibit antigen presentation by autoimmune disease-associated class II major histocompatibility molecules

Fiorenza Falcioni, Kouichi Ito, Damir Vidović, +14

Nature Biotechnology

Autoimmune DiseaseAutoantibody ProductionMedicinePeptoidImmunology +9

Enantioselective synthesis of tropanes by reaction of rhodium-stabilized vinylcarbenoids with pyrroles

Huw M. L. Davies, Nicholas Huby

Tetrahedron Letters

Rhodium-stabilized VinylcarbenoidsChemical EngineeringEngineeringOrganic ChemistryChemistry +4

Diastereoselectivity Enhancement in Cyclopropanation and Cyclopropenation Reactions of Chiral Diazoacetate Esters Catalyzed by Chiral Dirhodium(II) Carboxamides

Michael P. Doyle, Marina Protopopova, Bridget D. Brandes, +3

Synlett

Diastereoselectivity EnhancementChemical EngineeringEngineeringChiral AuxiliariesChiral Diazoacetate Esters +10

Characterization of a Novel Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor with a Unique Mechanism of Action for Cancer Therapy

Sherif Daouti, Huisheng Wang, Wenhui Li, +13

Cancer Research

Preclinical <i>In vivo</i> Evaluation of Efficacy, Pharmacokinetics, and Pharmacodynamics of a Novel MEK1/2 Kinase Inhibitor RO5068760 in Multiple Tumor Models

Sherif Daouti, Brian Higgins, Kenneth Kolinsky, +13

Molecular Cancer Therapeutics