IFN-α Induces Early Lethal Lupus in Preautoimmune (New Zealand Black × New Zealand White)F1 but Not in BALB/c Mice

Alexis Mathian, Arthur G. Weinberg, Mike Gallegos, +2

The Journal of Immunology

Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases: Antinucleosome antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus

Zahir Amoura, Sophie Koutouzov, Henri Chabre, +5

Arthritis & Rheumatism

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

Zahir Amoura, Henri Chabre, Sophie Koutouzov, +4

Arthritis & Rheumatism

Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus. Correlation with serum antinucleosome antibody titers and absence of clear association with disease activity

Zahir Amoura, Jean‐Charles Piette, Henri Chabre, +5

Arthritis & Rheumatism

Presence of nucleosome‐restricted antibodies in patients with systemic lupus erythematosus

Henri Chabre, Zahir Amoura, Jean‐Charles Piette, +3

Arthritis & Rheumatism

Systemic IFN‐α drives kidney nephritis in B6.<i>Sle123 </i>mice

Anna‐Marie Fairhurst, Alexis Mathian, John E. Connolly, +9

European Journal of Immunology

Renal PathologyImmunologyRenal InflammationPathologyHumoral Response +20

IFNα kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model

Daniel Zagury, Hélène Le Buanec, Alexis Mathian, +9

Proceedings of the National Academy of Sciences

ImmunologyPathologyClinical ManifestationsImmunotherapyInflammation +16

Interferon‐α induces unabated production of short‐lived plasma cells in pre‐autoimmune lupus‐prone (NZB×NZW)F1 mice but not in BALB/c mice

Alexis Mathian, Mike Gallegos, Virginia Pascual, +2

European Journal of Immunology

Humoral ResponseImmune RegulationImmunologyImmunologic MechanismCurrent Sle Therapies +25

Impairment of membrane phosphoinositide metabolism by aminoglycoside antibiotics: streptomycin, amikacin, kanamycin, dibekacin, gentamicin and neomycin.

P. Marché, Sophie Koutouzov, Arlette Girard

Journal of Pharmacology and Experimental Therapeutics

Quantitative radioligand assays using de novo–synthesized recombinant autoantigens in connective tissue diseases: New tools to approach the pathogenic significance of anti-RNP antibodies in rheumatic diseases

Ana Maria Yamamoto, Zahir Amoura, Catherine Johannet, +5

Arthritis & Rheumatism