Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione <i>S</i>-Transferases

Luca Federici, Carlo Lo Sterzo, Silvia Pezzola, +4

Cancer Research

Crystal StructureChemoprevention StrategyChemical BiologyPharmaceutical ChemistryTumor Biology +14

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines

A. C. SAU, Giuseppe Filomeni, Silvia Pezzola, +8

Molecular BioSystems

6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione <i>S</i>-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1–mediated MDR in small cell lung cancer

Giuseppe Filomeni, Paola Turella, Maria Luisa Dupuis, +6

Molecular Cancer Therapeutics

Antitumor ActivityChemoprevention StrategyCell DeathMultidrug ResistanceCancer Biology +14

A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons

Christian Barbato, Silvia Pezzola, Cinzia Caggiano, +4

Frontiers in Cellular Neuroscience

Amyloid βMicrorna SpongeSynaptic SignalingSocial SciencesAlzheimer's Disease +17

Selective inhibition of miR‐92 in hippocampal neurons alters contextual fear memory

Gisella Vetere, Christian Barbato, Silvia Pezzola, +6

Hippocampus

Synthesis and structure–activity relationship of new cytotoxic agents targeting human glutathione-S-transferases

Dante Rotili, Anastasia De Luca, Domenico Tarantino, +6

European Journal of Medicinal Chemistry

Structure–activity RelationshipHuman Glutathione-s-transferasesBiochemistryNew Cytotoxic AgentsMedicine +4

In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma

Francesca Pellizzari Tregno, A. C. SAU, Silvia Pezzola, +7

European Journal of Cancer

Tumor BiologyMedicinal ChemistryOncologyHuman MelanomaMedicine +9

A paper-based electrochemical sensor for H2O2 detection in aerosol phase: Measure of H2O2 nebulized by a reconverted ultrasonic aroma diffuser as a case of study

Luca De Fiore, Vincenzo Mazzaracchio, Pierluca Galloni, +5

Microchemical Journal

H2o2 DetectionAerosol PhaseChemical EngineeringEngineeringGas Sensor +8

The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells

Alessandro Ascione, Maurizio Cianfriglia, Maria Luisa Dupuis, +5

Cancer Chemotherapy and Pharmacology

Hematological MalignancyHealth SciencesMrp1-mediated Multidrug ResistanceGlutathione S-transferase InhibitorMedicine +8

An Accurate Approach for Computational pKa Determination of Phenolic Compounds

Silvia Pezzola, Samuele Tarallo, Alessandro Iannini, +4

Molecules