Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion

Zhifei Xu, Zezheng Pan, Ying Jin, +10

Autophagy

High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity

Zhifei Xu, Ying Jin, Hao Yan, +6

Toxicology Letters

Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib

Zhifei Xu, Ying Jin, Zizheng Gao, +9

Autophagy

Discovery of <i>N</i>-((3<i>S</i>,4<i>S</i>)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1<i>H</i>-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity

Jinxin Che, Xiaoyang Dai, Jian Gao, +13

Journal of Medicinal Chemistry

PTX3 from vascular endothelial cells contributes to trastuzumab-induced cardiac complications

Zhifei Xu, Zizheng Gao, Huangxi Fu, +13

Cardiovascular Research