Wee Guan Lim

The PKCα-D294G Mutant Found in Pituitary and Thyroid Tumors Fails to Transduce Extracellular Signals

Yimin Zhu, Qihan Dong, Bee Jen Tan et al. · Cancer Research · 2005 · 31 citations

Medicine, Cell Biology, Oncology +17

The Last 10 Amino Acid Residues beyond the Hydrophobic Motif Are Critical for the Catalytic Competence and Function of Protein Kinase Cα

S.S. Yeong, Yimin Zhu, Derek J. Smith et al. · Journal of Biological Chemistry · 2006 · 20 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling

Wee Guan Lim, Benito C. Tan, Y ZHU et al. · Cellular Signalling · 2006 · 18 citations

Life Sciences, Cell Biology, Molecular Biology +7

The C-terminus of PRK2/PKNγ is required for optimal activation by RhoA in a GTP-dependent manner

Wee Guan Lim, Xiao Chen, Junping Liu et al. · Archives of Biochemistry and Biophysics · 2008 · 15 citations

Life Sciences, Biochemistry, Molecular Biology +10

The very C-terminus of protein kinase Cɛ is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1☆

Yimin Zhu, Derek J. Smith, Chandra Verma et al. · Cellular Signalling · 2005 · 12 citations

Life Sciences, Biochemistry, Molecular Biology +17