21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/b3eb9795ffa7b0d3.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T41a,The use of epinephrine and phenylephrine in the management of open-angle glaucoma is well known to ophthalmologists. Reports of clinical investigations on the influence of epinephrine and phenlyephrine on the intraocular pressure have frequently appeared in the international literature.^1-5Thus far, none of these reports have mentioned that a significant rise in intraocular pressure could occur in open-angle glaucoma after the topical application of epinephrine or phenylephrine. We have found three patients in whom the pressure actually rose although the angles remained wide and open. The purpose of this paper is to present information concerning the various effects (on intraocular pressure, facility of aqueous outflow, and rate of flow) of epinephrine and phenylephrine topically applied to glaucomatous and to normal eyes.

Procedures and Materials

The effects of epinephrine and phenylephrine individually were examined in 19 patients. Twelve had open-angle glaucoma, and seven were normal controls. Seven of the twelve23:T43e,The purpose of this study was to produce experimental retinal detachments caused by retinal breaks resulting from alterations of the vitreous gel. Thus, an effort was made to simulate the pathogenesis of human rhegmatogenous retinal detachments in which vitreoretinal traction is an essential factor.^1-3Clinical observations suggest that the presence of blood in the vitreous of human eyes may cause profound changes in the vitreous gel⁴resulting in rhegmatogenous retinal detachment. Retinal detachments have been produced in animals by a variety of methods since the initial attempt by Chodin in 1875.⁵These attempts may be divided into five general categories: Mechanical production of a retinal break.5-10 Induced vitreous changes.5,10-16 Mechanical separation of the retina.7, 17-19 Injection of chemicals into the anterior chamber, subconjunctival, or suprachoroidal space.20-25 Ligation of the optic nerve.26 With most of these methods, the retinal detachments spontaneously reattached. Techniques producing long-standing retinal detachments were

#	Concept	H-Index	Publications	Citations
1	Medicine	4	4	200
2	Anesthesia	1	1	59
3	Diabetes	1	1	86
4	Pharmacology	1	1	59
5	Diabetes Complications	1	1	86

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