Non-viral precision T cell receptor replacement for personalized cell therapy

Susan P. Foy, Kyle Jacoby, Daniela A. Bota, +51

Nature

Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy

Cristina Puig-Saus, Barbara Sennino, Songming Peng, +53

Nature

Pd-1 Blockade TherapyCancer ImmunosurveillanceImmunologyImmune Checkpoint InhibitorCd4 T Cell Responses +3

Contact‐dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB

Stephanie K. Aoki, Juliana C. Malinverni, Kyle Jacoby, +8

Molecular Microbiology

Coupling endonucleases with DNA end–processing enzymes to drive gene disruption

Michael T. Certo, Kamila Gwiazda, Ryan Kuhar, +13

Nature Methods

Nucleic Acid ChemistryNatural SciencesNucleic Acid BiochemistryOligonucleotideMolecular Biology +4

Membrane Proteases and Aminoglycoside Antibiotic Resistance

Aaron Hinz, Samuel Lee, Kyle Jacoby, +1

Journal of Bacteriology

Membrane ProteasesAntimicrobial Resistance GeneMembrane ProteaseBiochemistryAntibiotics +11

Tapping natural reservoirs of homing endonucleases for targeted gene modification

Ryo Takeuchi, Abigail R. Lambert, Amanda Nga-Sze Mak, +6

Proceedings of the National Academy of Sciences

In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods

Sowmya Pattabhi, S. N. Lotti, Mason P. Berger, +7

Molecular Therapy — Nucleic Acids

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences

Alexandra E. Grier, Stephen Burleigh, Jaya Sahni, +8

Molecular Therapy — Nucleic Acids

TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

Christopher T. Lux, Sowmya Pattabhi, Mason P. Berger, +11

Molecular Therapy — Methods & Clinical Development

High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins

Kamila Gwiazda, Alexandra E. Grier, Jaya Sahni, +10

Molecular Therapy

Systems BiologyGenome SurgeryAav TransductionNatural SciencesImmunology +13