Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection

Panpan Hou, Shuliang Chen, Shilei Wang, +8

Scientific Reports

Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection

Zhepeng Liu, Shuliang Chen, Xu Jin, +15

Cell & Bioscience

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Panpan Hou, Kongxiang Yang, Penghui Jia, +13

Cell Research

Cell AutophagyMitophagyAutoimmune DiseaseViral PathogenesisImmunology +6

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220

Panpan Hou, Chao Wu, Yuchen Wang, +11

Cancer Research

Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

Qiankun Wang, Shuliang Chen, Qiaoqiao Xiao, +9

Retrovirology

Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases

Panpan Hou, Yuxin Lin, Zibo Li, +10

Cellular and Molecular Immunology

InflammationAutophagy Receptor Ccdc50Autoimmune DiseaseImmunologyAntiviral Response +6

CDK4/6 Inhibition Enhances Oncolytic Virus Efficacy by Potentiating Tumor-Selective Cell Killing and T-cell Activation in Refractory Glioblastoma

Jingshu Xiao, Jiaming Liang, Junjie Fan, +16

Cancer Research

The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5

Lang Bu, Huan Wang, Panpan Hou, +12

Frontiers in Immunology

An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis

Panpan Hou, Penghui Jia, Kongxiang Yang, +9

Proceedings of the National Academy of Sciences

CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3

Yuxin Lin, Zibo Li, Yicheng Wang, +8

EMBO Reports

InflammationCell AutophagyAnti-inflammatorySignal TransductionImmunology +9