Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies

Christian A. Di Buduo, Lindsay S. Wray, Lorenzo Tozzi, +13

Blood

Megakaryocytes Contribute to the Bone Marrow-Matrix Environment by Expressing Fibronectin, Type IV Collagen, and Laminin

Alessandro Malara, Manuela Currao, Cristian Gruppi, +6

Stem Cells

Bone Marrow-matrix EnvironmentMegakaryocytes ContributeImmunologyCellular PhysiologyRegenerative Medicine +16

Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes

Alessandra Balduini, Isabella Pallotta, Alessandro Malara, +5

Journal of Thrombosis and Haemostasis

Developmental BiologyMolecular PhysiologySignal TransductionCell AdhesionAdhesive Receptors +12

Megakaryocytes of patients with MYH9-related thrombocytopenia present an altered proplatelet formation

Alessandro Malara, Stefania Badalucco, Valeria Bozzi, +4

Thrombosis and Haemostasis

Blood CellPathologyProplatelet TipsCellular PhysiologyPlatelet Release +14

Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A

Alessandro Malara, Cristian Gruppi, Paola Rebuzzini, +6

Blood

Proplatelet formation in heterozygous Bernard‐Soulier syndrome type Bolzano

Alessandra Balduini, Alessandro Malara, Alessandro Pecci, +6

Journal of Thrombosis and Haemostasis

Chromosome DynamicsDevelopmental BiologyMendelian DisorderGenetic DisorderGenetics +5

Outside-In Signalling Generated by a Constitutively Activated Integrin αIIbβ3 Impairs Proplatelet Formation in Human Megakaryocytes

Loredana Bury, Alessandro Malara, Paolo Gresele, +1

PLoS ONE

Thrombopoietin/TGF-<i>β</i>1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis

Vittorio Abbonante, Christian A. Di Buduo, Cristian Gruppi, +12

Stem Cells

Cellular PhysiologyTranscriptional RegulationTissue DevelopmentSignaling PathwayCell Regulation +14

EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

Alessandro Malara, Cristian Gruppi, Vittorio Abbonante, +12

The Journal of Experimental Medicine

Creation and implantation of acellular rat renal ECM-based scaffolds

Andrea Peloso, Jacopo Ferrario, B. Maiga, +12

Organogenesis

Tissue EngineeringEngineeringBiomaterials DesignBiofabricationTissue Transplantation +17