Junya Ishida

Rational Approaches to Discovery of Orally Active and Brain-Penetrable Quinazolinone Inhibitors of Poly(ADP-ribose)polymerase

Kouji Hattori, Yoshiyuki Kido, Hirofumi Yamamoto et al. · Journal of Medicinal Chemistry · 2004 · 95 citations · Full text

Drug Target, Bioorganic Chemistry, Orally Active +18

A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2 H)-pyridinyl)propyl]-4(3 H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia

Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 82 citations

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling

Junya Ishida, Hirofumi Yamamoto, Yoshiyuki Kido et al. · Bioorganic & Medicinal Chemistry · 2005 · 82 citations · Full text

Molecular Docking, Sbdd Analysis, Medicinal Chemistry +12

Bismuth bromide-catalyzed reductive coupling of carbonyl compounds and its application to the synthesis of novel crownophanes

Naoki Komatsu, Junya Ishida, Hitomi Suzuki · Tetrahedron Letters · 1997 · 78 citations

Carbonyl Compounds, Chemical Engineering, Cross-coupling Reaction +8

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP‐ribose) polymerase‐1/2 inhibitors

Akinori Iwashita, Kouji Hattori, Hirofumi Yamamoto et al. · FEBS Letters · 2005 · 75 citations

Pharmaceutical Science, Bioorganic Chemistry, Quinoxaline Derivatives +18