The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

Ziyang Fu, Bin Huang, Jinle Tang, +13

Nature Communications

Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling

Xing‐Ding Zhang, Veerabhadran Baladandayuthapani, Heather Lin, +30

Cancer Cell

Proteasome Inhibitor SensitivityModulates Proteasome CapacityMedicineMultiple MyelomaTumor Suppressor +6

Novel CD7-specific nanobody-based immunotoxins potently enhanced apoptosis of CD7-positive malignant cells

Jinle Tang, Jialu Li, Xuejun Zhu, +13

Oncotarget

Immunotherapy based on bispecific T‐cell engager with <scp>hIgG</scp>1 Fc sequence as a new therapeutic strategy in multiple myeloma

Jianxuan Zou, Dan Chen, Yunhui Zong, +6

Cancer Science

Hematological MalignancyCancer ImmunosurveillanceFc SequenceMedicineImmunology +11

Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation

Senthilkumar Palaniyandi, Xiaoming Liu, Sivakumar Periasamy, +8

Mucosal Immunology

InflammationCd23-mediated Ige TranscytosisInflammatory Lung DiseaseAllergyLung Inflammation +7

Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease

Yunxia Xu, Ke Chen, Juanli Pan, +11

International Journal of Biological Macromolecules

ImmunologyAntiviral Drug DevelopmentAntiviral TherapyCovid-19 TreatmentAntiviral Drug +3

HMGB1 Promotes Mitochondrial Dysfunction–Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation

Lin Qi, Xue Sun, Feng-E Li, +17

PLoS ONE

Cell AutophagyNeurodegenerative DiseasesMitophagyExpression Hmgb1Mitochondrial Function +13

A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency

Salima Daou, Manisha Talukdar, Jinle Tang, +14

Proceedings of the National Academy of Sciences

Nck inhibits NGF and basic FGF induced PC12 cell differentiation via mitogen-activated protein kinase-independent pathway.

Shayna Rockow, Jinle Tang, Weili Xiong, +1

PubMed

Artificial intelligence for medicine 2025: Navigating the endless frontier

Huiyu Xu, Tao Chen, Tao Huang, +14

The Innovation Medicine