Paul R. Leger

<i>MYCN</i> drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

Eli Grunblatt, Nan Wu, Huajia Zhang et al. · Genes & Development · 2020 · 86 citations · Full text

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

Paul R. Leger, Dennis X. Hu, Bérenger Biannic et al. · Journal of Medicinal Chemistry · 2020 · 70 citations · Full text

Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity <i>In Vitro</i> and <i>In Vivo</i>

Yamini M. Ohol, Michael Sun, Gene Cutler et al. · Molecular Cancer Therapeutics · 2020 · 37 citations

Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy

Jeffrey J. Jackson, Grant M. Shibuya, Buvana Ravishankar et al. · Journal of Medicinal Chemistry · 2022 · 11 citations · Full text