(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray

Dylan Chou, Hsien‐Yu Peng, Tzer-Bin Lin, +8

Neuropharmacology

Midbrain Periaqueductal GrayStress HormonePsychiatryBehavioral NeuroscienceStress +8

Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats

Ming‐Chun Hsieh, Cheng‐Yuan Lai, Yu‐Cheng Ho, +4

Scientific Reports

Pain MedicineGeneticsEpigenetic ChangeNeuropathic PainMolecular Pain +20

Examining the effects of learning motivation and of course design in an instructional simulation game

Yung-Chia Chang, Hsien‐Yu Peng, Hui-Cheng Chao

Interactive Learning Environments

Educational PsychologyEducationSimulation Video GameLearning-by-doingInstructional Design Models +19

Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression

Yu-Cheng Ho, Tzer-Bin Lin, Ming-Chun Hsieh, +5

Neuropsychopharmacology

Stress HormonePsychiatryBehavioral NeuroscienceMood SymptomDepression +6

Modulation of Nerve Injury–induced HDAC4 Cytoplasmic Retention Contributes to Neuropathic Pain in Rats

Tzer-Bin Lin, Ming-Chun Hsieh, Cheng‐Yuan Lai, +5

Anesthesiology

Melatonin relieves neuropathic allodynia through spinal <scp>MT</scp>2‐enhanced <scp>PP</scp>2Ac and downstream <scp>HDAC</scp>4 shuttling‐dependent epigenetic modification of <i>hmgb1</i> transcription

Tzer‐Bin Lin, Ming‐Chun Hsieh, Cheng‐Yuan Lai, +5

Journal of Pineal Research

Pain DisordersBehavioral AllodyniaPain MedicineEpigenetic ChangeMolecular Pain +20

Melatonin impedes Tet1‐dependent mGluR5 promoter demethylation to relieve pain

Ming‐Chun Hsieh, Yu‐Cheng Ho, Cheng‐Yuan Lai, +5

Journal of Pineal Research

Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic–urethra reflex activity in rats

Hsien‐Yu Peng, Gin‐Den Chen, Kwong‐Chung Tung, +7

Pain

Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund’s adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats

Hsien‐Yu Peng, Gin‐Den Chen, Ming-Chun Hsieh, +3

Pain

Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes

Hsien‐Yu Peng, Gin‐Den Chen, Shin‐Da Lee, +7

Pain

Pain MedicineNeuropathic PainNeuroactive SteroidsGlucocorticoidSpinal Reflex Potentiation +18