Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans

Marc Vermeir, Ineke Naessens, Bart Remmerie, +8

Drug Metabolism and Disposition

Absorption, Metabolism, and Excretion of Darunavir, a New Protease Inhibitor, Administered Alone and with Low-Dose Ritonavir in Healthy Subjects

Marc Vermeir, Sophie Lachau‐Durand, Geert Mannens, +3

Drug Metabolism and Disposition

Disposition, Metabolism, and Excretion of [ ¹⁴ C]Doripenem after a Single 500-Milligram Intravenous Infusion in Healthy Men

Iolanda Cirillo, Geert Mannens, Cor Janssen, +8

Antimicrobial Agents and Chemotherapy

PharmacotherapyBioanalysisToxicologyAnalytical ChemistryToxicological Aspect +17

Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters

Karel P.M. Heirwegh, J A T P Meuwissen, Marc Vermeir, +1

Biochemical Journal

Proteinlipid InteractionEquilibrium ParametersEngineeringLipid MovementMembrane Transport +15

In vitro studies on the metabolism of trabectedin (YONDELIS®) in monkey and man, including human CYP reaction phenotyping

Marc Vermeir, Alex Hemeryck, Filip Cuyckens, +7

Biochemical Pharmacology

Animal PhysiologyBiochemistryMedicineHuman Cyp ReactionPhysiology +7

Absorption; metabolism and excretion of a single oral dose of 14c-paliperidone 1mg in healthy subjects (PAL-053)

Marc Vermeir, Sandra Boom, Ineke Naessens, +3

Pharmacopsychiatry

Unchanged DrugHealthy SubjectsPharmacotherapy14C-paliperidone 1MgMolecular Pharmacology +18

Radioassay of UDP-glucuronyltransferase-catalysed formation of bilirubin monoglucuronides and bilirubin diglucuronide in liver microsomes

Marc Vermeir, Florent Vanstapel, Norbert Blanckaert

Biochemical Journal

Molecular BiologyChemical BiologyBiosynthesisGas ChromatographyBioanalysis +19

PIII-78Absorption, metabolism and excretion of a single oral dose of 14C-paliperidone 1 mg in five healthy male subjects

Marc Vermeir, Sandra Boom, Ineke Naessens, +2

Clinical Pharmacology & Therapeutics

Psychotropic MedicationPsychopharmacologyPharmacotherapyTotal Excretion14C-paliperidone 1 +20

Interaction of 7-n-alkoxycoumarins with cytochrome <i>P</i>-4502 and their partitioning into liposomal membranes. Assessment of methods for determination of membrane partition coefficients

Marc Vermeir, N. Boens, K.P.M. Heirwegh

Biochemical Journal

Proteinlipid InteractionLipid MovementChemical BiologyBioanalysisLiposome Partitioning +16

Modelling of interaction of basic lipophilic ligands with cytochrome P-450 reconstituted in liposomes. Determination of membrane partition coefficients of S-( − )-nicotine and N,N-diethylaniline from spectral binding studies and fluorescence quenching

Marc Vermeir, Noël Boens, Karel P.M. Heirwegh

Biochimica et Biophysica Acta (BBA) - Biomembranes

Membrane Partition CoefficientsProteinlipid InteractionEngineeringBiochemistryLipid Chemistry +8