mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

Naomi X.Y. Ling, Adrian Kaczmarek, Ashfaqul Hoque, +12

Nature Metabolism

Signal TransductionMolecular PhysiologySignaling PathwayCell RegulationNutrient Stress +10

Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep

Shervi Lie, Janna L. Morrison, Olivia Williams-Wyss, +9

American Journal of Physiology-Endocrinology and Metabolism

NutritionFertilityHuman GrowthGeneticsDeep Sequencing Methodology +24

Periconceptional Undernutrition Programs Changes in Insulin-Signaling Molecules and MicroRNAs in Skeletal Muscle in Singleton and Twin Fetal Sheep1

Shervi Lie, Janna L. Morrison, Olivia Williams-Wyss, +9

Biology of Reproduction

NutritionGeneticsMaternal UndernutritionInsulin SignalingMetabolic Syndrome +21

The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1

Shervi Lie, Tingting Wang, Briony E. Forbes, +2

Scientific Reports

Mtorc1 ActivityMolecular BiologyCancer BiologyCellular PhysiologyReactive Nitrogen Specie +19

Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling

Gabriella Forte, Elizabeth A. Colby Davie, Shervi Lie, +7

Journal of Cell Science

Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis

Susan J. Hinze, Matilda R. Jackson, Shervi Lie, +4

Translational Psychiatry

The contribution of non-essential<i>Schizosaccharomyces pombe</i>genes to fitness in response to altered nutrient supply and target of rapamycin activity

Shervi Lie, Peter Banks, Conor Lawless, +2

Open Biology

Maternal undernutrition around the time of conception and embryo number each impact on the abundance of key regulators of cardiac growth and metabolism in the fetal sheep heart

Shervi Lie, Shaun Sim, I. Caroline McMillen, +6

Journal of Developmental Origins of Health and Disease

Exposure to rosiglitazone, a PPAR-γ agonist, in late gestation reduces the abundance of factors regulating cardiac metabolism and cardiomyocyte size in the sheep fetus

Shervi Lie, Melisa Hui, I. Caroline McMillen, +6

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Cardiac MuscleCardiovascular PharmacologyKey FactorsInsulin SignalingOxidative Stress +24

Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection With Toxoplasma gondii

Shervi Lie, E Rochet, Erik Segerdell, +8

Frontiers in Immunology