High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.

Keisuke Ozaki, Tokuo Sukata, Shinji Yamamoto, +8

PubMed

Drinking WaterResidual AlleleUrologyChemoprevention StrategyUrinary Bladder Carcinogenesis +13

Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation

Yoshihito Deguchi, Tomoya Yamada, Y Hirose, +9

Toxicological Sciences

PathologyCell DeathHepatic Cyp2b InductionTumor BiologyOxidative Stress +19

Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats.

Kaori Miyata, Setsuko Yabushita, Tokuo Sukata, +5

The Journal of Toxicological Sciences

Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages

Tokuo Sukata, Kayo Sumida, Masahiko Kushida, +4

Toxicology Letters

Tumor BiologyHepatologyEarly StagesLiver PhysiologyRat Hepatocarcinogenesis +11

Circulating MicroRNAs in Serum of Human K-ras Oncogene Transgenic Rats With Pancreatic Ductal Adenocarcinomas

Setsuko Yabushita, Katsumi Fukamachi, Hajime Tanaka, +7

Pancreas

Detailed low‐dose study of 1,1‐b™IS(<i>p</i>‐chlorophenyl)‐2,2,2‐ trichloroethane carcinogenesis suggests the possibility of a hormetic effect

Tokuo Sukata, Satoshi Uwagawa, Keisuke Ozaki, +9

International Journal of Cancer

Evaluation of a 5-day Hershberger assay using young mature male rats. Methyltestosterone and p,p'-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo.

Osamu Sunami, Takeshi Kunimatsu, Tomoya Yamada, +7

The Journal of Toxicological Sciences

Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: Possible mechanisms

Masahiko Kushida, Tokuo Sukata, Satoshi Uwagawa, +6

Toxicology and Applied Pharmacology

HepatologyPossible MechanismsMedicineLiver PhysiologyPathology +10

Functional genomics may allow accurate categorization of the benzimidazole fungicide benomyl: lack of ability to act via steroid-receptor-mediated mechanisms

Tomoya Yamada, Kayo Sumida, Koichi Saito, +6

Toxicology and Applied Pharmacology

Bioorganic ChemistryMedicineGeneticsAccurate CategorizationMedicinal Fungi +8

Organ-specific, carcinogen-induced increases in cell proliferation in p53-deficient mice.

Tokuo Sukata, Keisuke Ozaki, Satoshi Uwagawa, +5

PubMed

Tumor BiologyDrinking WaterChemoprevention StrategyOncogenic AgentMedicine +11