Kurt Deshayes

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev, John W. Blankenship, Sarah M. Wayson et al. · Cell · 2007 · 1.2K citations · Full text

Inflammation, Cytokine, Induce Autoubiquitination +12

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari et al. · The Journal of Cell Biology · 2009 · 797 citations · Full text

Immunology, Cell Death, Neuroinflammation +19

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

Eugene Varfolomeev, Tatiana Goncharov, Anna Fedorova et al. · Journal of Biological Chemistry · 2008 · 532 citations · Full text

Apoptosis, Immunology, Immune Regulation +21

Structure-guided design of a selective BCL-XL inhibitor

Guillaume Lessène, Peter E. Czabotar, Brad E. Sleebs et al. · Nature Chemical Biology · 2013 · 370 citations · Full text

Drug Target, Medicine, Rational Drug Design +4

c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

Jasmin N. Dynek, Tatiana Goncharov, Erin C. Dueber et al. · The EMBO Journal · 2010 · 336 citations · Full text