Chinnadurai Mani

RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance

Ranganatha R. Somasagara, Sebastian M. Spencer, Kaushlendra Tripathi et al. · Oncogene · 2017 · 70 citations · Full text

Genome Instability, Oncology, Medicine +9

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells

Chinnadurai Mani, Shirisha Jonnalagadda, Jojireddy Lingareddy et al. · Breast Cancer Research · 2019 · 66 citations · Full text

Gli1 Protein Regulates the S-phase Checkpoint in Tumor Cells via Bid Protein, and Its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors

Kaushlendra Tripathi, Chinnadurai Mani, Reagan Barnett et al. · Journal of Biological Chemistry · 2014 · 40 citations · Full text

Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

Kaushlendra Tripathi, Chinnadurai Mani, David W. Clark et al. · Oncotarget · 2016 · 29 citations · Full text

The multifunctional protein PACS-1 is required for HDAC2- and HDAC3-dependent chromatin maturation and genomic stability

Chinnadurai Mani, Kaushlendra Tripathi, Shan Luan et al. · Oncogene · 2020 · 24 citations · Full text

Chromatin, Genome Instability, Chromatin Structure +13